Demonstrates novel biochemical binding properties in FcγRI, indicating stable interactions during acidosis.
R substitutions demonstrate an implication for electron conjugation. Examining key sites at this binding FcγRI-IgG interface, our data demonstrate that these two codons have evolved in humans to be relatively insensitive to shifts in pH promoting a more stable interaction with the Fc portion of IgG during diseases that promote acidosis.
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Young et al. (2026) studied this question.
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