Why the study?
Does high-risk radiotherapy increase the risk of localized coronary artery stenosis in patients with breast cancer?
Population
199 patients from a Swedish breast cancer cohort diagnosed from 1970 to 2003 who underwent coronary…
Comparison
High-risk radiotherapy or irradiated left-sided… vs Low-risk radiotherapy, no radiotherapy, or…
Design
Cohort
Authors
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Left-sided breast radiotherapy was associated with higher severe LAD stenosis risk; supports targeted surveillance but leaves causal dose effects open for trials.
Does high-risk radiotherapy increase the risk of localized coronary artery stenosis in patients with breast cancer?
High-risk radiotherapy for left-sided breast cancer is associated with a significantly increased risk of severe coronary artery stenosis in specific irradiated hotspot areas, such as the mid/distal LAD.
Nilsson et al. (2011) studied this question.
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