Alleviating Gut Inflammation with Latilactobacillus curvatus Isolated from Kimchi

We focused on the anti-inflammatory properties of Latilactobacillus curvatus, formerly called Lactobacillus curvatus, isolated from kimchi. In a mouse model of dextran sulfate sodium (DSS)-induced colitis, treatment with L. curvatus significantly decreased the colitis by inhibiting the expression of a proinflammatory cytokine and receptor that disrupt intestinal epithelial structural integrity. The disease activity index combined scores for weight loss, stool consistency, and bleeding showed that disease activity was markedly lower in the DSS+ probiotics group. Histological analyses showed that treatment with L. curvatus strains protected the structural integrity of the intestinal epithelial layer and mucin-secreting goblet cells from DSS-induced damage, with only slight infiltration of immune cells. In serum and DSS-treated colon tissues, mRNA expression levels of IL-6, TNF R1, iNOS, and COX2 of L. curvatus-treated group were significantly suppressed. These results indicated that L. curvatus ameliorates the colitis in intestine and reduces IBD pathogenesis of host.