Why the study?
Does serial D-dimer measurement safely guide the discontinuation of anticoagulation in outpatients with a first VTE?
Population
1010 outpatients with a first VTE after at least 3 months of anticoagulation
Comparison
Serial D-dimer measurements using commercial… vs Patients who resumed anticoagulation or refused it
Design
Cohort
Follow-up
up to 2 years
Authors
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May support D-dimer-guided discontinuation in selected VTE patients; leaves open need for randomized confirmation before practice change.
Does serial D-dimer measurement safely guide the discontinuation of anticoagulation in outpatients with a first VTE?
Serial D-dimer measurement is suitable in clinical practice to identify VTE patients who can safely discontinue anticoagulation.
Palareti et al. (2014) studied this question.
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