Why the study?
Does the Wells rule combined with D-dimer testing accurately exclude deep vein thrombosis in outpatients with suspected DVT across different subgroups?
Does the Wells rule combined with D-dimer testing accurately exclude deep vein thrombosis in outpatients with suspected DVT across different subgroups?
The combination of an unlikely Wells score and a negative D-dimer safely excludes DVT in most patients, but is neither safe nor efficient in cancer patients, and requires a modified rule for suspected recurrent events.
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Supports safe DVT rule-out without imaging in most outpatients; confirms pooled evidence while underscoring limitations in cancer and recurrent cases.
Geersing et al. (2014) studied this question.
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