Why the study?
To evaluate left ventricular volumes, mass, and function using CMR after TAVR in patients with severe aortic stenosis.
Does TAVR improve LV volumes, mass, and function as assessed by CMR in patients with severe aortic stenosis?
Does TAVR improve LV volumes, mass, and function as assessed by CMR in patients with severe aortic stenosis?
Answers are grounded in this paper and cite their sources.
TAVR is associated with significant reverse left ventricular remodeling and improved ejection fraction within 6-15 months as assessed by CMR.
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is increasingly used to treat patients with severe aortic stenosis (AS). Cardiovascular magnetic resonance imaging (CMR) provides reliable and reproducible estimates for assessment of cardiac structure and function after TAVR. The goal of this study was to conduct a systematic review and meta-analysis of the literature to assess left ventricular (LV) volumes, mass and function by CMR after TAVR. METHODS: Using Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines, we searched PubMed and Embase for studies reporting CMR findings before and at least 1 month after TAVR. Main factors of interest were LV end-diastolic volume index (LVEDVi), LV end-systolic volume index (LVESVi), LV mass index (LVMi), and left ventricular ejection fraction (LVEF). Standardized mean differences (SMD) were pooled by random effects meta-analytic techniques. RESULTS: (IQR: 11.8 to 18.3) for LVMi. The median increase for LVEF was 3.4% (IQR 1.0 to 4.6%). CONCLUSIONS: CMR demonstrates reverse LV remodeling occurrs within 6-15 months after TAVR, with reductions in LVEDVi, LVESVi and LVMi, and increased LVEF.
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Mehdipoor et al. (2020) studied this question.
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