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July 10, 2023Proceedings of the National Academy of SciencesOpen Access

Increased neutralization potency and breadth elicited by a SARS-CoV-2 mRNA vaccine forming virus-like particles

Peng Zhang Samantha Falcone Yaroslav Tsybovsky Mamta Singh Vinay Gopan Huiyi Miao Yuna Seo Denise Rogers Isabella Renzi Yen‐Ting Lai Elisabeth Narayanan Guillaume B. E. Stewart-Jones Sunny Himansu Andrea Carfı́Anthony S. Fauci Paolo Lusso

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Abstract

mRNA developed neutralizing antibodies effective against different variants of concern. These data demonstrate that the Gag/VLP mRNA platform can be successfully applied to vaccines against different agents for the prevention of infectious diseases of global relevance.

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Zhang et al. (2023) studied this question.

synapsesocial.com/papers/69f8cf835e060e036dd0f7c7 https://doi.org/10.1073/pnas.2305896120

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