Why the study?
Does rapamycin reduce smooth muscle cell proliferation and obstructive arteriopathy in experimental models of elastin deficiency?
Population
Experimental models of elastin deficiency including Eln and Eln mice, and cell cultures of smooth muscle…
Design
Preclinical
Authors
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Hypothesis-generating for mTOR inhibition in elastin arteriopathy; leaves open clinical translation given absent survival benefit and growth retardation.
Does rapamycin reduce smooth muscle cell proliferation and obstructive arteriopathy in experimental models of elastin deficiency?
mTOR inhibition with rapamycin reduces smooth muscle cell proliferation and aortic obstruction in preclinical models of elastin deficiency, suggesting a potential pharmacological strategy for diffuse arteriopathy.
Li et al. (2013) studied this question.
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