EXOC6B promotes cilial elongation via autophagy-dependent protein turnover.

Kailash Chand; Sai Latha Sabbu; Deeksha Agrawal; Tanuja Kosuri; Katta M. Girisha; Kishore V L Parsa

doi:10.1016/j.bbrc.2026.153828

April 30, 2026

EXOC6B promotes cilial elongation via autophagy-dependent protein turnover.

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Key Points

The research aims to investigate the role of EXOC6B in cilia elongation and its mechanism through autophagy.
Examined the interaction between EXOC6B and ciliary proteins
Assessed the induction of basal autophagy
Analyzed changes in cilia length in response to EXOC6B activation
EXOC6B significantly promotes cilia elongation through enhanced autophagy
Basal autophagy induction correlates positively with cilia length enhancement
Disruption of autophagy diminishes the lengthening effect of EXOC6B

Implication

Shows that EXOC6B enhances cilia length via basal autophagy activation, suggesting new avenues for cellular function modulation.

Abstract

is critical for interaction with ciliary proteins, induction of basal autophagy and cilia length enhancement. Taken together, we show that EXOC6B promotes cilia length through the activation of basal autophagy.

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Cite This Study

Chand et al. (2026) studied this question.

synapsesocial.com/papers/69f988e215588823dae17d4d https://doi.org/10.1016/j.bbrc.2026.153828

View at Publisher

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EXOC6B promotes cilial elongation via autophagy-dependent protein turnover.

Key Points

Implication

Abstract

Discussion

Cite This Study

EXOC6B promotes cilial elongation via autophagy-dependent protein turnover.

Key Points

Implication

Abstract

Discussion

Cite This Study

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