Demonstrates the link between heavy chain C-terminal sequences and monoclonal antibody expression in various isotypes, suggesting optimization strategies.
was found to broadly influence the expression of other industrially relevant IgG mAb isotypes, including IgG2 and IgG4. This study establishes a connection between the HC C-terminal nucleotide sequence and mAb expression titer, offering insights for optimizing the expression of Fc-containing molecules.
No takes yet. Share an insight, caveat, or question.
Carlson et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: