Shows no improvement in central respiratory drive with daytime CO₂ normalization in neuromuscular disease, suggesting further investigation is needed.
OBJECTIVE: decreases following ventilation. METHODS: slope. Recruitment reflected real-world clinical practice, and data were analyzed post hoc. RESULTS: slope remained unchanged (p = 0.338). The median slope in the NMD group was 0.011 (0.004-0.030), compared with 0.187 (0.150-0.244) in controls (p < 0.001). Breath-holding time was prolonged in 17 individuals and remained stable throughout the follow-up. CONCLUSIONS: slope indicates that daytime PaCO₂ normalization is unlikely to be mediated by enhanced central chemosensitivity. Further studies are needed to clarify the physiological mechanisms responsible for hypercapnia correction with NIHMV.
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Vito et al. (2026) studied this question.
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