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Demonstrates controlled PPG release in both organic and aqueous media, indicating potential for precise chemical processes.
Photolabile protecting groups (PPGs) enable spatiotemporal control of chemical and biological processes, yet multistimuli-regulated systems remain rare. Here we report a triple-stimuli platform integrating light, base, and acid to control PPG release. Photoirradiation of diarylethenes (DAEs) under basic conditions generates stable 9,10-dihydrophenanthrene (9,10-DHP) intermediates that activate hemiaminal ethers and undergo acid-promoted aromatization to release the alcohol group. Distinct fluorescence changes allow real-time monitoring in both organic and aqueous media.
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Huang et al. (2026) studied this question.
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