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Review of mirabegron efficacy and safety in frail older adults with overactive bladder, suggesting its advantages over antimuscarinics.
-Adrenoreceptor agonists like mirabegron offer a pharmacological alternative over antimuscarinics, which may be associated with intolerable side effects in older patients. While mirabegron has demonstrated efficacy and tolerability in community-dwelling older adults, prospective studies on its use in frail older adults remain limited. Here, we review available evidence on use of mirabegron in older adults and frail older adults, including safety, tolerability and efficacy. Evidence suggests that mirabegron has favourable safety and side effect profiles, decreases OAB symptoms, and improves quality of life. Mirabegron remains an acceptable alternative to antimuscarinic treatment in older adults and frail older adults.
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Shaw et al. (2026) studied this question.
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