Regenerative Biofield Modulation: A Live Core–PSE Structured-Energy Framework for Bioelectromagnetic and Plasma-Mediated Tissue Repair

This preprint proposes Regenerative Biofield Modulation as a theoretical and preclinical framework for investigating whether a Live Core–Plasma Sandwich Envelope (PSE) architecture can generate controlled, measurable, and safety-bounded structured-energy outputs relevant to tissue-repair biology. The Live Core is defined as a field-confined high-energy core, configured as either a solid rotor or plasma structure, suspended and coupled through shaped electromagnetic fields rather than direct mechanical contact. The PSE is proposed as an active double-skin plasma boundary layer for frequency-controlled stability, field interaction, diagnostics, and output conditioning. The central hypothesis is that high-energy Live Core dynamics should not be applied directly to biological systems, but may be isolated, characterized, filtered, and down-converted into biologically testable signal windows related to pulsed electromagnetic fields, endogenous wound bioelectricity, cold atmospheric plasma, photobiomodulation, controlled redox signaling, and force-vector modulation. The framework also includes contactless physiological-state inference and constrained artificial intelligence-based parameter optimization as secondary research pathways for safety monitoring and adaptive exposure design. Staged validation requirements are defined, including field characterization, dosimetry, sham and heat-matched controls, thermal and electromagnetic safety testing, plasma chemistry monitoring, in vitro repair assays, mitochondrial and redox endpoints, antimicrobial testing, and reproducibility criteria. This paper does not claim clinical efficacy, human regeneration, disease treatment, or direct therapeutic use. Instead, it presents a falsifiable research pathway for testing whether structured electromagnetic, plasma-derived, photonic, redox, thermal, and mechanical-force outputs can influence cell viability, migration, oxidative-stress recovery, angiogenesis, collagen remodeling, antimicrobial activity, and tissue-repair markers under controlled laboratory conditions.