June 15, 1999Circulation
Effect of Pacing Chamber and Atrioventricular Delay on Acute Systolic Function of Paced Patients With Congestive Heart Failure
Why the study?
Does atrial-synchronous ventricular pacing at different sites and AV delays improve acute systolic function in patients with congestive heart failure and LV conduction disorder?
Population
27 congestive heart failure patients with severe left ventricular systolic dysfunction and LV conduction…
Comparison
Atrial-synchronous ventricular pacing in the… vs Nonpaced beats and comparison between different…
Design
Other
Follow-up
acute (immediate)
Authors
Discussion
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Member takes
Implication
LV pacing maximizes acute systolic function in CHF with conduction delay; extends acute hemodynamic data but leaves long-term outcomes open.
Structured PICO
Does atrial-synchronous ventricular pacing at different sites and AV delays improve acute systolic function in patients with congestive heart failure and LV conduction disorder?
P
Population
27 congestive heart failure (CHF) patients with severe left ventricular (LV) systolic dysfunction and LV conduction disorder in normal sinus rhythm.
I
Intervention
Atrial-synchronous ventricular pacing in the right ventricle (RV), left ventricle (LV), or both ventricles simultaneously (BV) at preselected AV delays in a repeating 5-paced/15-nonpaced beat sequence.
C
Comparator
Nonpaced beats (baseline) and comparison between different pacing sites (RV vs LV vs BV).
O
Outcome
Immediate changes in maximum LV pressure derivative (LV+dP/dt) and aortic pulse pressure (PP).surrogate
In CHF patients with wide QRS, LV stimulation provides the maximum acute hemodynamic benefit, which is optimized at a patient-specific AV delay.
Cite This Study
Auricchio et al. (1999) studied this question.