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October 27, 2017Anesthesia & AnalgesiaOpen Access

A Prospective International Multicentre Cohort Study of Intraoperative Heart Rate and Systolic Blood Pressure and Myocardial Injury After Noncardiac Surgery: Results of the VISION Study

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Why the study?

Are intraoperative extremes in heart rate and systolic blood pressure associated with myocardial injury after noncardiac surgery?

Population

Up to 16,061 noncardiac surgical patients from the prospective international VISION cohort study.

Design

Cohort

Follow-up

30 days

Authors

TATom AbbottRPRupert M. PearseAAAndrew Archbold

Discussion

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Overview

These associations warrant caution but should not yet change practice; leaves open whether optimizing intraoperative hemodynamics reduces MINS.

Structured PICO

Are intraoperative extremes in heart rate and systolic blood pressure associated with myocardial injury after noncardiac surgery?

P
Population
Up to 16,061 noncardiac surgical patients from the prospective international VISION cohort study.
I
Intervention
Intraoperative hemodynamic extremes (maximum HR >100 bpm, minimum HR <55 bpm, maximum SBP >160 mm Hg, minimum SBP <100 mm Hg)
O
Outcome
Myocardial injury after noncardiac surgery (MINS), defined by an elevated serum troponin T adjudicated as due to an ischemic etiology, within 30 days after surgeryhard clinical

Intraoperative tachycardia (>100 bpm) and hypotension (<100 mm Hg) are significantly associated with an increased risk of myocardial injury and mortality within 30 days after noncardiac surgery.

Cite This Study

Abbott et al. (2017) studied this question.

synapsesocial.com/papers/69fa8a079fa336b96d47d903https://doi.org/10.1213/ane.0000000000002560
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk of Major Adverse Cardiac Events Following Noncardiac Surgery in Patients With Coronary Stents2013 · 344 citations
  2. 2Intraoperative Tachycardia and Hypertension Are Independently Associated with Adverse Outcome in Noncardiac Surgery of Long Duration2002 · 198 citations
  3. 3Tachycardia-Induced Subendocardial Necrosis in Acutely Instrumented Dogs with Fixed Coronary Stenosis1999 · 28 citations
  4. 4Intraoperative Hypotension and 1-Year Mortality after Noncardiac Surgery2009 · 361 citations
  5. 5Importance of arterial pulse pressure as a predictor of coronary heart disease risk in PROCAM2005 · 149 citations