Why the study?
Does adding sildenafil to bosentan improve 6-minute walk distance in patients with Eisenmenger syndrome?
Does adding sildenafil to bosentan improve 6-minute walk distance in patients with Eisenmenger syndrome?
In patients with Eisenmenger syndrome, adding sildenafil to bosentan therapy did not significantly improve 6-minute walk distance but did increase resting oxygen saturation.
Does not support adding sildenafil to bosentan for 6MWD gains in Eisenmenger syndrome; challenges dual ERA/PDE5i therapy for functional outcomes.
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Iversen et al. (2010) studied this question.
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