No-wash Immunosensors Based on Superhydrophilic Covalent Organic Framework Nanosheets with Aggregation-Induced Emission for Detecting Carbohydrate Antigen 19-9

Key Points

• The aim is to enhance the aggregation-induced emission activity and hydrophilicity of AIE-covalent organic framework nanosheets.
• Developed no-wash immunosensors based on superhydrophilic covalent organic framework nanosheets.
• Investigated the aggregation-induced emission activity of the nanosheets for improved detection.
• Utilized sandwich-type fluorescence-on immunosensors for carbohydrate antigen detection.
• Enhanced sensitivity of immunosensors observed with improved aggregation-induced emission.
• Demonstrated superior performance in detecting carbohydrate antigen 19-9 using modified nanosheets.