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This probe improves targeted delivery and imaging in lung cancer, suggesting better surgical outcomes.
) while ensuring prolonged intratumoral retention. Validated in both subcutaneous and orthotopic lung cancer models, the probe demonstrated exceptional specificity and clearly delineated the tumor boundaries. By integrating targeted delivery with enzyme-activated covalent anchoring, this work provides a robust strategy for high-contrast, dual-mode imaging and precise surgical navigation in hypoxic malignancies.
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Wang et al. (2026) studied this question.
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