PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 6, 2026Human Mutation0 citationsOpen Access

Role of HNRNPA3 in Breast Cancer and Immune Microenvironment: Multiomics Insights

Exploring the Role of HNRNPA3 in Breast Cancer Progression, Immune Microenvironment, and Therapeutic Sensitivity: A Multiomics and Functional Prediction Study

View Full Paper
Ask AI
Bookmark
Share

Authors

LGLijie GongYXYang XuWGWeihui Guo

Discussion

Loading...

Member takes

Overview

Multiomics analysis identifies HNRNPA3's role in tumor progression and immune modulation in breast cancer, suggesting therapeutic targets.

Key Points

  • This research aims to investigate the role of HNRNPA3 in breast cancer progression and its impact on the immune microenvironment.
  • Integrated multiomics analysis of HNRNPA3 using TCGA and GEO datasets
  • Differential expression analysis and survival analysis
  • Functional enrichment and immune microenvironment characterization
  • Drug sensitivity analysis for HNRNPA3-related therapies
  • HNRNPA3 is upregulated in breast cancer tissues, linked to advanced tumor grade and poor prognosis
  • Involvement of HNRNPA3 in cell cycle regulation and immune-related pathways
  • High HNRNPA3 expression affects immune cell distribution, particularly CD4+ T cells
  • Identification of drug agents, including talazoparib, targeting HNRNPA3 pathways

Cite This Study

Gong et al. (2026) studied this question.

synapsesocial.com/papers/69fa8e8904f884e66b530c9chttps://doi.org/10.1155/humu/5519745
View Full Paper
Ask AI
Bookmark
Share