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May 6, 2026Annals of Work Exposures and Health

135 Chrysotile asbestos accelerates tumour development in mouse models of mesothelioma and lung cancer

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Authors

PFPooyeh FarahmandSLSarah LaingJDJennifer Doig

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Overview

Data analysis indicates Chrysotile asbestos links to increased Lung Cancer incidence in Scotland, suggesting underestimated risks.

Key Points

  • This research aims to understand the role of Chrysotile asbestos in tumor development and its correlation with Lung Cancer and Mesothelioma in Scotland.
  • Analyzed geographic distribution of Lung Cancer incidence vs. Mesothelioma across 17 Scottish Health Boards from 1998 to 2022.
  • Used dose-controlled delivery of Chrysotile and Amosite asbestos fibres into mouse models to study tumor development.
  • Measured correlation between incidence rates and Pearson Coefficient.
  • Found a strong correlation (R = 0.848) between Lung Cancer and Mesothelioma incidence.
  • Intrapleural injection of Chrysotile or Amosite resulted in accelerated tumor onset in Mesothelioma mouse models.
  • Repeated oral delivery of Chrysotile fibers accelerated tumor initiation in KRas-driven Lung Adenocarcinoma models.

Cite This Study

Farahmand et al. (2026) studied this question.

synapsesocial.com/papers/69fa8e8904f884e66b530dadhttps://doi.org/10.1093/annweh/wxag024.121
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study)2024 · 2 citations
  2. 2Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1 -mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment2024 · 12 citations
  3. 3Dual phase modeling of Chrysotile carcinogenesis from 3D cell transformation to orthotopic tumors2026
  4. 4Abstract 1468: Low exposures to amphibole or serpentine asbestos in germline Bap1-mutant mice induce mesotheliomacharacterized by an immunosuppressive tumor microenvironment2024
  5. 5Data from Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment2024