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May 6, 2026Glomerular DiseasesOpen Access

An “All-in-One” Kidney Biopsy in AIDS: Crescentic Immune Complex–Mediated Glomerulonephritis, CD8-Driven Interstitial Nephritis, and Superimposed Thrombotic Microangiopathy

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Authors

TSThanawat SevaphaiJSJerasit SurintrspanontTTTheerachai Thammathiwat

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Overview

This report demonstrates concurrent crescentic glomerulonephritis and thrombotic microangiopathy in HIV, indicating significant immune dysregulation.

Key Points

  • To describe a novel case of advanced HIV infection exhibiting complex kidney pathology.
  • Case report of a 43-year-old male with HIV presenting with kidney failure and nephrotic syndrome.
  • Diagnostic kidney biopsy to assess for glomerular and interstitial injuries.
  • Use of antiretroviral therapy, corticosteroids, cyclophosphamide, and plasma exchange.
  • Patient presented with crescentic immune complex–mediated glomerulonephritis and acute thrombotic microangiopathy.
  • Despite treatment, kidney function recovery was incomplete, and the patient remained dialysis-dependent.
  • Findings highlight significant immune dysregulation associated with HIV.

Cite This Study

Sevaphai et al. (2026) studied this question.

synapsesocial.com/papers/69fa8e8904f884e66b530ef9https://doi.org/10.1159/000552365
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