improved survival, reduced inflammatory responses, and accelerated inflammatory resolution without compromising bacterial clearance. These findings support a modular bacteriophage engineering strategy that combines bacterial killing, real-time infection monitoring, and local attenuation of LPS-driven inflammation, offering a potential approach for improving bacteriophage-based treatment of Gram-negative infections. IMPORTANCE: group, and the treatment was associated with lower inflammatory peaks, improved survival, and preserved bacterial clearance. Together, these results support a modular route for bacteriophage-based strategies that couple bacterial killing with real-time reporting and local control of LPS associated inflammation.
Yu et al. (Mon,) studied this question.