Pd-Catalyzed Site-Selective Dehydrogenative Alkenyl Etherification of Tyrosine Residues in Peptides and Proteins

Xia Liu; Wei Zeng; Jianjun Zhang; Peng Wang; Neeli Satyanarayana; Qing Zhu

doi:10.1039/d6qo00358c

January 1, 2026Organic Chemistry Frontiers

Pd-Catalyzed Site-Selective Dehydrogenative Alkenyl Etherification of Tyrosine Residues in Peptides and Proteins

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to develop a selective method for the alkenyl etherification of tyrosine residues in proteins.
Palladium-catalyzed reaction
Cross-coupling alkenyl etherification
Synthesis of tyrosine-derived alkenyl ethers
Moderate to good yields of alkenyl ethers
Site-selective modification of tyrosine residues
Facilitated synthesis of diverse compounds

Implication

Palladium-catalyzed reaction enables selective etherification of tyrosine in proteins, suggesting new synthesis methods.

Abstract

We report a palladium-catalyzed selective cross-coupling alkenyl etherification of the C(sp²)-O bond in tyrosine side chains, enabling the synthesis of diverse tyrosine-derived alkenyl ethers in moderate to good yields. This...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69fa97ce04f884e66b531a5a https://doi.org/10.1039/d6qo00358c

View Full Paper

Ask AI

Bookmark

Share

Pd-Catalyzed Site-Selective Dehydrogenative Alkenyl Etherification of Tyrosine Residues in Peptides and Proteins

Key Points

Implication

Abstract

Discussion

Cite This Study

Pd-Catalyzed Site-Selective Dehydrogenative Alkenyl Etherification of Tyrosine Residues in Peptides and Proteins

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading