Identification of MYMK , TWIST2 , and NEDD4L as Key Susceptibility Genes for Nonsyndromic Orofacial Clefts Through Insights From Syndromic Cases

Key Points

• To identify key genes associated with nonsyndromic orofacial clefts using insights from syndromic cases.
• Analysis of susceptibility genes for nonsyndromic orofacial clefts (NSOC) based on existing syndromic gene data.
• Comparison of loci identified through syndromic cases against standard GWAS results.
• Identification of MYMK, TWIST2, and NEDD4L as significant genes in the context of NSOC.
• Revealed loci that standard GWAS may have missed, enhancing understanding of cleft pathogenesis.