Differentiation of Disaccharide Isomers via Diagnostic-Ion-Weighted Spectral Library Searching using Data from Tandem MS Analysis of Chloride Adducts

Shixiang Xu; Abraham K. Badu-Tawiah; Santosh R. Acharya; Ruth Speidel

doi:10.1039/d6an00268d

January 1, 2026The Analyst

Differentiation of Disaccharide Isomers via Diagnostic-Ion-Weighted Spectral Library Searching using Data from Tandem MS Analysis of Chloride Adducts

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Key Points

This research aims to differentiate disaccharide isomers using tandem mass spectrometry data.
Utilized diagnostic-ion-weighted spectral library searching.
Analyzed tandem MS data from chloride adducts of disaccharide isomers.
Focused on identifying rare sugars and their isomers.
Demonstrated effective differentiation of over 50 saccharide isomers.
Found potential applications in food science and pharmaceuticals.
Highlighted the significance of structural complexity in isomerization.

Implication

Analysis reveals disaccharide isomer differentiation in food science, suggesting applications in pharmaceuticals.

Abstract

Rare sugars, comprising of over 50 known saccharide isomers, have broad significance in food science, pharmaceuticals, and biomedical applications. However, the inherent structural complexity (due to isomerization) and low natural...

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69fa986a04f884e66b532234 https://doi.org/10.1039/d6an00268d

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Differentiation of Disaccharide Isomers via Diagnostic-Ion-Weighted Spectral Library Searching using Data from Tandem MS Analysis of Chloride Adducts

Key Points

Implication

Abstract

Discussion

Cite This Study

Differentiation of Disaccharide Isomers via Diagnostic-Ion-Weighted Spectral Library Searching using Data from Tandem MS Analysis of Chloride Adducts

Key Points

Implication

Abstract

Discussion

Cite This Study

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