What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

This study aims to quantify the global prevalence and mortality of sickle cell disease in youth aged under-5 and under-20.

May 6, 2026British Journal of Haematology

Contemporary global burden of sickle cell anaemia under‐5 and under‐20: A systematic review and meta‐analysis

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Authors

KPKelly PimentaSt. Jude Children's Research Hospital JEJeffrey EdwardsSt. Jude Children's Research Hospital MRMeredith RayUniversity of Memphis

Discussion

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Implication

Systematic review quantifies prevalence and mortality of sickle cell disease in youth under-5 and under-20, indicating need for improved screening and diagnostics.

Key Points

This study aims to quantify the global prevalence and mortality of sickle cell disease in youth aged under-5 and under-20.
Conducted a systematic review and meta-analysis
Included studies reporting sickle cell disease prevalence or mortality published from 2017 to 2023
Assessed eligible studies for quality and conducted random-effects meta-analyses
Stratified pooled estimates by age group, study design, and country classification
Identified 57 studies with data from over 3.6 million individuals
Under-5 prevalence of sickle cell disease was 0.008 (95% CI: 0.004-0.016)
Global under-20 prevalence was 0.009 (95% CI: 0.005-0.017)
Under-20 cause-specific mortality proportion was 0.029 (95% CI: 0.001-0.621)

Cite This Study

Pimenta et al. (2026) studied this question.

synapsesocial.com/papers/69faa25e04f884e66b532e4d https://doi.org/10.1111/bjh.70501

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Implication

Systematic review quantifies prevalence and mortality of sickle cell disease in youth under-5 and under-20, indicating need for improved screening and diagnostics.

Contemporary global burden of sickle cell anaemia under‐5 and under‐20: A systematic review and meta‐analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Contemporary global burden of sickle cell anaemia under‐5 and under‐20: A systematic review and meta‐analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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