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May 3, 2026

Temporal stratification of promoter-proximal versus enhancer VDR binding directs vitamin D-responsive transcription.

Priman Alfred Fau Antonio Neme Sabine Seuter Carsten Carlberg

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BACKGROUND: ) activates the vitamin D receptor (VDR) in immune cells, altering the epigenome to drive diverse responses.

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Fau et al. (2026) studied this question.

synapsesocial.com/papers/69faa28f04f884e66b5332b2 https://doi.org/10.1186/s13072-026-00677-y

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Genome-wide identification of vitamin D receptor-regulated enhancer RNAs reveals epigenetic regulation of CYP24A1 transcriptionOriginal Research · 2026
2The Vitamin D Receptor Story: Discovery, Control, and Genomic ReachOriginal Research · 2026
3Transcriptional Synergism between Vitamin D-responsive Elements in the Rat 25-Hydroxyvitamin D3 24-Hydroxylase (CYP24) PromoterOriginal Research · 1996 · 121 citations
4Identification of a Novel Vitamin D Response Element from the Rat GenomeOriginal Research · 1997 · 1 citations
5Vitamin D-Related Signaling and Epigenetic Regulation: Evidence from Experimental, Observational, and Interventional StudiesRandomized Controlled Trial · 2026 · 1 citations

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