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May 6, 2026Cancer Science0 citationsOpen Access

super-enhancer roles in scirrhous gastric cancer and stromal field influence

Super‐Enhancer Formation in Scirrhous Gastric CAFs , and the Presence of a Stromal Field in Non‐Cancerous Tissues

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Authors

YYYoshimi YasukawaNHNaoko HattoriYLYu-yu Liu

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Overview

Research shows scirrhous CAFs enhance gastric cancer cell migration via super-enhancers, indicating non-cancerous fibroblasts may also promote tumors.

Key Points

  • This research explores the origin and epigenetic basis of scirrhous cancer-associated fibroblasts (CAFs) in gastric cancer.
  • Analyzed conditioned medium from scirrhous and non-scirrhous CAFs.
  • Examined migration effects on gastric cancer cells.
  • Investigated the role of TGFβ1 and NF-κB in CAFs.
  • Explored therapeutic targeting using BET bromodomain inhibitors.
  • Conditioned medium from scirrhous CAFs increased cancer cell migration by 2-4 folds.
  • Active super-enhancers were identified in scirrhous CAFs.
  • Targeting super-enhancers reduced migration-promoting effects of CAFs.

Cite This Study

Yasukawa et al. (2026) studied this question.

synapsesocial.com/papers/69faa2e204f884e66b5336cchttps://doi.org/10.1111/cas.70408
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