Analysis demonstrates that PrfH boosts ribosome repair efficiency in translation involving colicin E3 damage, indicating a novel mechanism for ribosome restoration.
ribosome repair system based on recombinant components, we demonstrated that RtcB2 alone could repair E3-rRNAse cleaved 30S subunits and 70S ribosomes. The peptide chain release factor homolog (PrfH), which is able to hydrolyse peptidyl-tRNA bound by colicin-cleaved ribosomes, boosts RtcB2 ligation efficiency for damaged ribosomes engaged in translation.
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Maviza et al. (2026) studied this question.
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