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May 6, 2026SHILAP Revista de lepidopterologíaOpen Access

Comparative molecular analysis of colorectal cancer in Saudi Arabia: distinct genetic alterations and clinical features

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Authors

MAMaha‐Hamadien AbdullaJAJumanah AlshenaifiMVMansoor‐Ali Vaali‐Mohammed

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Overview

Comparative molecular analysis reveals distinct genetic mutations in colorectal cancer, suggesting tailored treatment strategies in Saudi Arabia.

Key Points

  • This research aims to analyze the molecular and phenotypic profiles of colorectal cancer in the Saudi population.
  • Conducted Whole Exome Sequencing of 50 Saudi colorectal cancer patients with MSS adenocarcinoma tumors.
  • Compared findings with tumor cohorts from MD Anderson Cancer Center and The Cancer Genome Atlas.
  • Examined the frequency of specific mutations and clinical features such as age and tumor location.
  • Lower frequencies of KRAS mutations in Saudi patients (6.5%) compared to MDACC (45.0%) and TCGA (41.1%).
  • Significantly fewer APC mutations found in Saudi patients (47.8%) compared to MDACC (77.9%) and TCGA (79%).
  • Higher occurrence of TP53 mutations in Saudi patients (50.0%) compared to MDACC (35.9%) and TCGA (43.0%).
  • Greater percentage of Saudi CRC patients have sigmoid disease (41.7% vs. 24.4% at MDACC).
  • Younger average age at diagnosis for Saudi patients (58 years) compared to MDACC (62 years).

Cite This Study

Abdulla et al. (2026) studied this question.

synapsesocial.com/papers/69faa2e204f884e66b533823https://doi.org/10.3389/fonc.2026.1792016
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants2025
  2. 2Colorectal cancer incidence and clinicopathological patterns in Saudi Arabia, 2013–2023: A national registry analysis with exploratory estimation of attributable risk factor burden2026
  3. 3Comparison of early-onset and average-onset colorectal cancer in Saudi Arabia: A multicenter retrospective cohort study2026
  4. 4Colorectal cancer incidence in Saudi Arabia, 2002–2023: Age-specific trends and implications for screening and prevention2026 · 1 citations
  5. 5Screening, awareness and challenges for colorectal cancer treatment in Saudi Arabia: an update2024 · 3 citations