Integrated characterization reveals pharmacokinetics of paeoniflorin and mangiferin in rats, indicating metabolic gender differences.
< 1 h), with paeoniflorin and atractylenolide III showing significantly higher systemic exposure. Notably, the AUC of hypaconine and mangiferin was markedly greater in female rats, indicating a gender-related difference in metabolism. This work provides the first comprehensive chemical composition spectrum of KLG and clarifies its potential bioactive compounds, offering new insights for the material basis research and active component screening of Chinese herbal medicine compound preparations.
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Cheng et al. (2026) studied this question.
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