Key result
Spotty calcification is linked to ~0.4% greater percent atheroma volume progression vs. no calcification.
Why the study?
The relationship between spotty calcification within coronary plaques and the progression of atherosclerotic disease had not been investigated.
Does the presence of spotty calcification predict accelerated progression of coronary atherosclerosis in stable patients with coronary artery disease?
Population
1,347 stable patients with angiographic coronary artery disease
Comparison
Patients with spotty calcification vs patients with no calcification
Design
Cohort study with serial intravascular ultrasound imaging
Authors
Loading...
Spotty calcification identified by intravascular ultrasound is a marker for more extensive coronary atherosclerosis and accelerated disease progression despite medical therapy.
Cohort (n=1,347)
Does the presence of spotty calcification predict accelerated progression of coronary atherosclerosis in stable patients with coronary artery disease?
Absolute Event Rate: 0.43% vs 0.02%
p-value: p=0.002
Spotty calcification identified by intravascular ultrasound is a marker for more extensive coronary atherosclerosis and accelerated disease progression despite medical therapy.
Kataoka et al. (2012) conducted a cohort in Angiographic coronary artery disease (n=1,347). Spotty calcification vs. No calcification was evaluated on Progression of percent atheroma volume (PAV) (p=0.002). Spotty calcification was associated with greater progression of percent atheroma volume compared to no calcification (+0.43% vs. +0.02%; p=0.002).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: