Why the study?
Does increased preload induce troponin I degradation independently of myocardial ischemia in isolated rat hearts?
Does increased preload induce troponin I degradation independently of myocardial ischemia in isolated rat hearts?
Calpain-mediated troponin I proteolysis is driven by elevations in preload rather than ischemia, suggesting preload-induced degradation could impair long-term myocardial function.
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Preload-induced TnI degradation may occur without ischemia; leaves open calpain inhibition for load-related injury in vivo.
Feng et al. (2001) studied this question.
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