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May 6, 2026JACC Heart Failure0 citations

From Loop Diuretics to Closed-Loop Decongestion

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Authors

WMWilfried MüllensMEMarnicq Van EsSNSankar D. Navaneethan

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“By continuously quantifying urine output and intermittently measuring sodium excretion, the system targets the most relevant physiological endpoint in [acute HF] – natriuresis – and translates it into real-time therapeutic adjustments. This directly addresses one of the central weaknesses of curr...”

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Müllens et al. (2026) studied this question.

synapsesocial.com/papers/69fadb3403f892aec9b1e965https://doi.org/10.1016/j.jchf.2026.103067
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