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Objective: The objective of this study was to determine the PO 2 at 50% hemoglobin oxygenation (P 50 ) of feline hemoglobin (Hb). Design: Prospective in vitro laboratory study. Setting: Research laboratory. Animals: Blood from 10 healthy cats. Interventions: Individual blood samples were equilibrated with calibrated gases of 95, 21, 8, 5, 4, and 2.5% oxygen for tonometric analysis. Measurements: Partial pressure of oxygen (PO 2 ), oxygen content, oxyhemoglobin saturation, methemoglobin (MetHb), carboxyhemoglobin (COHb), Hb, packed cell volume, hydrogen ion concentration (pH), and partial pressure of carbon dioxide (PCO 2 ) were measured in duplicate for each blood sample by tonometry. The P 50 was calculated from both PO 2 /oxyhemoglobin saturation and PO 2 /oxygen content (per gram of Hb) curves. Main results: The P 50 from the PO 2 /oxyhemoglobin saturation curve was 35.6 mmHg and from the PO 2 /oxygen content (per gram of Hb) curve was 36.2 mmHg. Conclusions: The oxyhemoglobin dissociation curve for the cat is shifted to the right, and thus, feline Hb has lower oxygen affinity compared with human and canine Hb.
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Herrmann et al. (2005) studied this question.
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