Incidence of silent cerebral events detected by MRI in patients with atrial fibrillation undergoing pulsed field ablation vs thermal ablation: A systematic review and network meta-analysis

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and catheter ablation has been demonstrated to achieve superior success rates compared with antiarrhythmic drugs. However, this procedure entails certain risks, including silent cerebral events (SCEs), which may affect cognitive function. This network meta-analysis aimed to determine the global incidence of SCEs in patients with AF undergoing catheter ablation and to compare the incidence across energy sources and catheter types. Our analysis included 86 trials involving 10,456 patients with AF, with a pooled SCE incidence of 19.1%. For pulsed field ablation, the incidence of SCEs was 14.4%; thermal ablation techniques showed rates of 17.7% for radiofrequency ablation, 20.8% for cryoballoon ablation, and 32.7% for laser ablation. No significant differences were found between pulsed field ablation and thermal ablation in SCE incidence. The comparison of SCE incidence between different catheter types revealed variations. The HD Mesh Ablator demonstrated the lowest incidence rate (15.1%), whereas the PVAC catheter had the highest (36.2%). The Farawave catheter had an incidence rate of 18.5% and showed no significant differences compared with most thermal catheters, except for the HD Mesh Ablator (relative risk, 0.15; 95% credible interval, 0.03-0.89). Our findings indicate that a substantial proportion of patients experience SCEs after catheter ablation for AF, with an overall incidence of approximately 19.1% occurring within 1 week (mostly within 72 hours) after ablation. No significant differences were observed in SCE incidence between pulsed field ablation and thermal ablation or between the Farawave catheter and most thermal catheters.