Why the study?
The association between genotypes and clinical outcomes, including left ventricular reverse remodeling, remains uncertain among pediatric patients with dilated cardiomyopathy.
Does the presence of sarcomere gene variants reduce left ventricular reverse remodeling in pediatric patients with dilated cardiomyopathy?
Population
123 pediatric patients with DCM from Japanese multi-institutional centers
Comparison
Sarcomere gene variants vs non-sarcomere gene variants vs no gene variants
Design
Multi-institutional cohort study
Authors
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Sarcomere variants associated with less LVRR in pediatric DCM; hypothesis-generating, requires prospective validation.
Does the presence of sarcomere gene variants reduce left ventricular reverse remodeling in pediatric patients with dilated cardiomyopathy?
Pediatric patients with dilated cardiomyopathy and sarcomere gene variants are less likely to experience left ventricular reverse remodeling compared to those with non-sarcomere or no gene variants.
Hirono et al. (2024) studied this question.