Population
Open-chest anesthetized dogs with normal coronary arteries
Comparison
Variation of diastolic pressure time index via… vs Normal baseline state
Design
Preclinical
Authors
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Does not support clinical use of DPTI/TTI ratios; leaves open translation of supply-demand mismatch to human subendocardial ischemia.
Subendocardial ischemia without anatomic coronary obstruction is driven by an imbalance between diastolic supply (DPTI) and systolic demand (TTI).
Buckberg et al. (1972) studied this question.
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