Genetic predisposition plays a major role in the pathogenesis of athero sclerosis and coronary heart disease. Genetic factors are modulated by environmental influence. Genotype by environmental interaction is one approach to inter and quantity this relationship. In the last few years, we also became aware that we can directly change our genetic makeup by a novel therapeutic approach using somatic gene transfer. This review describes gene-environment interactions and the role of somatic gene therapy in atherosderosis.
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Chan et al. (1994) studied this question.
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