8-epi PGF2α acts as a partial agonist on the TP-receptor, causing vasoconstriction in porcine and bovine coronary arteries with a potency approximately twice that of PGF2α.
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Species-specific coronary constriction by 8-epi PGF2α warrants caution extrapolating animal data; leaves open relevance to human vasospasm.
Kromer et al. (1996) studied this question.
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