Key result
Oral-gut microbiota dysbiosis is linked to cardiometabolic disease via systemic inflammation and endothelial dysfunction.
Understanding the oral-gut microbiota axis provides insights for innovative therapeutic strategies to prevent and manage cardiometabolic diseases.
The oral-gut microbiota axis plays a crucial role in cardiometabolic health. This review explores the interactions between these microbiomes through enteric, hematogenous, and immune pathways, resulting in disruptions in microbial balance and metabolic processes. These disruptions contribute to systemic inflammation, metabolic disorders, and endothelial dysfunction, which are closely associated with cardiometabolic diseases. Understanding these interactions provides insights for innovative therapeutic strategies to prevent and manage cardiometabolic diseases.
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Xu et al. (2025) conducted a review in Cardiometabolic diseases. Oral-gut microbiota axis was evaluated. The oral-gut microbiota axis contributes to systemic inflammation, metabolic disorders, and endothelial dysfunction, linking it to the development of cardiometabolic diseases.