Abstract Prader–Willi syndrome (PWS) is a rare genetic imprinting disorder characterized by hypotonia, hyperphagia, intellectual disability, endocrine abnormalities, and severe obesity. We report the case of a 13-year-old male adolescent presenting with progressive morbid obesity, respiratory distress, developmental delay, and hypogonadism. Clinical examination revealed a body mass index of 63.3 kg/m 2 , almond-shaped eyes, acanthosis nigricans, abdominal striae, and unilateral cryptorchidism. The patient was managed with strict caloric restriction and multidisciplinary supportive care, resulting in a weight reduction of 17 kg within 25 days and significant clinical improvement. This case highlights the importance of early recognition, molecular confirmation, and multidisciplinary management of PWS to prevent severe complications.
Kar et al. (Thu,) studied this question.