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May 7, 2026Advanced Materials Interfaces0 citationsOpen Access

Light‐Controlled Exposure of Cancer Cells to Reactive Oxygen Species Using Organic Semiconductor Thin Films (Adv. Mater. Interfaces 9/2026)

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JKJoe KayeImperial College LondonNMNiculina MironImperial College LondonBMBenjamin Fortes MayerImperial College London

Key Points

  • This research aims to explore a method for selectively inducing oxidative stress in cancer cells using light-activated interfaces.
  • Utilized organic semiconductor thin films to create a light-activated interface.
  • Generated an interfacial superoxide flux under visible light exposure.
  • Examined the spatial confinement of reactive oxygen species (ROS) to specific regions of cancer cells.
  • Demonstrated that light exposure yields a confined ROS patch.
  • Achieved selective ablation of cancer cells within the exposed region.
  • Showed the method is reagent-free and allows for thickness-tunable oxidative stress generation.

Abstract

Light-Activated Biointerfaces Visible light incident on an organic semiconductor thin film creates an interfacial superoxide flux, yielding a spatially confined “ROS patch” that ablates cells only within the exposed region - demonstrating reagent-free, thickness-tunable oxidative stress. More details can be found in the Research Article by Saif A. Haque, Ali Salehi-Reyhani, and co-workers (DOI: 10.1002/admi.202500899).

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Cite This Study

Kaye et al. (2026) studied this question.

synapsesocial.com/papers/69fbe382164b5133a91a2b7chttps://doi.org/10.1002/admi.70458
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