A robust Au–CC anchoring group greatly improves the signal stability of electrochemical aptamer-based sensors for in vivo measurements

Key Points

• This research aims to enhance signal stability in electrochemical aptamer-based sensors for drug monitoring.
• Developed an electrochemical aptamer-based sensor using Au–CC anchoring for drug monitoring.
• Conducted in vivo measurements to assess sensor performance.
• Evaluated signal stability and monitoring frequency of the sensor in live animals.
• The Au–CC anchoring group significantly improved signal stability of the sensors.
• The sensor enabled high-frequency, continuous drug monitoring.
• Demonstrated feasibility for real-time monitoring of drug pharmacokinetics in living animals.