This work demonstrates a mechanism that enhances γ-lactam synthesis in medicinal chemistry, suggesting potential applications in drug development.
-alkyl scope and diverse sulfur nucleophiles. Control and in situ NMR experiments supported a nucleophile-initiated mechanism, providing a streamlined route to functionally rich γ-lactam scaffolds for heterocycles and medicinal chemistry.
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Poletto et al. (2026) studied this question.
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