Research reveals targeting senescence improves blood–brain barrier integrity in midlife obesity, suggesting potential for dementia prevention.
senescent cells partially restored BBB integrity, improved NVC responses, and reduced neuroinflammation. Together, these findings identify cellular senescence as a mechanistic driver of midlife obesity-induced cerebrovascular and cognitive dysfunction and provide proof-of-concept that senescence-targeted therapies may preserve brain health in individuals with midlife obesity who are at risk for dementia.
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Negri et al. (2026) studied this question.
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