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May 7, 2026International Journal of Drug Research in Clinics

Hormonal Modulation and Transient Sacroiliac Joint Inflammation: A Narrative Review With a Hypothesis on Premenstrual Sacroiliitis in Hyperandrogenic Women

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Authors

STSepideh Tahsini TekantapehMHMehrzad HajialiloAIAfshin Iranpour

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Overview

Narrative review uncovers links between hormonal modulation and sacroiliac joint inflammation in hyperandrogenic women, suggesting further research is needed.

Key Points

  • This review evaluates the role of hormonal modulation on sacroiliac joint inflammation in women, focusing on hyperandrogenic conditions.
  • Reviewed literature on sacroiliac joint MRI findings in women.
  • Analyzed hormonal regulation of pelvic ligaments and connective-tissue remodeling.
  • Synthesize human, animal, biomechanical, and imaging studies qualitatively.
  • High prevalence of bone marrow edema in postpartum women (58-80%).
  • Transient sacroiliitis may be linked to hormonal fluctuations, particularly relaxin and estradiol.
  • Mechanisms include collagen breakdown and increased ligamentous laxity due to hormones.

Cite This Study

Tekantapeh et al. (2025) studied this question.

synapsesocial.com/papers/69fbe3ca164b5133a91a3106https://doi.org/10.34172/ijdrc.2025.e18
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1AB0876 PREVALENCE OF SPONDYLOARTHRITIS-RELATED LESIONS AT SACROILIAC JOINTS IN POSTPARTUM WOMEN AND INFLAMMATORY BOWEL DISEASE PATIENTS2024
  2. 2Rare Case Studies of Bilateral and Symmetric Sacroiliac Disease2024
  3. 3Assessment of Anatomical Variations in the Sacroiliac Joint Using Magnetic Resonance Imaging: A Retrospective Study of 840 Patients2026
  4. 4OP0284 FREQUENCY AND FACTORS ASSOCIATED WITH THE PRESENCE OF ACTIVE INFLAMMATORY AND STRUCTURAL CHANGES IN THE MRI OF SACROILIAC JOINTS: RESULTS FROM A POPULATION-BASED STUDY2024 · 1 citations
  5. 5Impact of pregnancy on sacroiliac imaging in women with axial spondyloarthritis: results of the analysis of the DESIR cohort2024 · 2 citations