Synthesis of N -Substituted Hydroxamic Acids through a Pentafluoropyridine-Mediated Procedure

Key Points

• This research aims to develop an efficient method for synthesizing N-substituted hydroxamic acids.
• Utilized a pentafluoropyridine-mediated procedure for synthesis
• Implemented a one-pot, three-step approach
• Avoided additional purification or intermediate isolation
• Achieved excellent yields for N-substituted hydroxamic acids
• Successfully generated unprotected analogues directly from parent carboxylic acids