PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 7, 2026Journal of Chromatography B0 citationsOpen Access

Evaluation of extraction methods for the determination of urinary sulfatides by LC-MS/MS

View Full Paper
JJJoachim JandaFBFriederike BürgerSGStefanie Geiger

Key Points

  • To evaluate different extraction methods for urinary sulfatides using LC-MS/MS.
  • Conducted batch experiments to extract sulfatides from urine
  • Assessed four different extraction techniques
  • Evaluated extraction efficiencies and matrix effects for 16 isoforms
  • Validated the most suitable extraction method
  • Presented application data from patient samples
  • Identified the most efficient extraction technique
  • Found significant matrix effects impacting sulfatide measurement

Abstract

• Batch experiments to extract sulfatides from urine were performed. • Four different extraction techniques were assessed. • Extraction efficiencies and matrix effects were evaluated for 16 isoforms. • The most suitable method has been validated. • Its application to patient samples is presented.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Janda et al. (2026) studied this question.

synapsesocial.com/papers/69fbe3ca164b5133a91a319chttps://doi.org/10.1016/j.jchromb.2026.125106
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Profiling and semi-quantitation of urine sulfatides by UHPLC-Orbitrap-HRMS2025 · 2 citations
  2. 2Quantification of plasma sulfatides by mass spectrometry: Utility for metachromatic leukodystrophy2016 · 22 citations
  3. 3Characterization of Urinary Sulfatides in Metachromatic Leukodystrophy Using Electrospray Ionization-Tandem Mass Spectrometry2001 · 54 citations
  4. 4Strategies for the Assessment of Matrix Effect in Quantitative Bioanalytical Methods Based on HPLC−MS/MS2003 · 5,315 citations
  5. 5Newborn Screening and Presymptomatic Treatment of Metachromatic Leukodystrophy2024 · 26 citations